Shohei Tada, Yoshitaka Yamazaki, Kazunori Yamamoto, Ken Fujii, Takahiro G. Yamada, Noriko F. Hiroi, *Akatsuki Kimura, *Akira Funahashi.
Switching from weak to strong cortical attachment of microtubules accounts for the transition from nuclear centration to spindle elongation in metazoans.
Heliyon 9, e25494 (2024)
DOI: https://doi.org/10.1016/j.heliyon.2024.e25494
In collaboration with Akira Funahashi (Keio University) and colleagues, we combined mechanical modeling and live-cell experiments to show that the transition from nuclear centration to spindle elongation depends on a shift in the strength of microtubule attachment to the cell cortex. This study revealed a key mechanical principle underlying the sequential microtubule-dependent processes within the cell.
