
Cell
Architecture
Laboratory
Cell architectonics is the study of the principles underlying how cells build themselves — without a central designer — through physical forces and self-organization.

Cell architectonics is the study of the principles underlying how cells build themselves — without a central designer — through physical forces and self-organization.


Our bodies are made up of countless cells. Within each of them lies a beautifully organized architecture — a harmony of structures working together, much like a finely designed building. Cell Architectonics is an emerging field that seeks to understand this “architecture of the cell” through the lens of mechanics and spatial design. Just as cities and buildings are shaped by architects, cells also possess intricate design principles — yet without an architect. They are self-organized systems, shaped solely by the laws of nature.

Our research aims to uncover how this “architecture without an architect” emerges and to explore the fundamental principles behind the wonder of life. Studying the tiny world within cells not only deepens our understanding of our own bodies but also offers new perspectives on the organization of societies and cities. For example, in a phenomenon called cytoplasmic streaming, small structural elements influence one another, spontaneously aligning to generate a coherent flow. This self-organized dynamic is reminiscent of how trends arise and shift within human society. By observing cells, we can glimpse the hidden harmony that connects life and society — and perhaps find inspiration for the design of the future.
→If you are interested in learning more about Cell Architecture, please refer to Quantitative Biology – A Practical Introduction by Akatsuki Kimura (Springer Nature Singapore, 2022).
News
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Successful Measurement of Membrane Viscosity
Our collaborative study with Dr. Yuka Sakuma (Tohoku University), conducted under the NIG-JOINT program, has been published, and a press release was i […] -
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Internship Students Join the Lab
This summer, two internship students have joined our laboratory to participate in ongoing research projects. -
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3D Simulation of Cytoplasmic Streaming
A collaborative study with Professor Takuji Ishikawa (Tohoku University) on the three-dimensional simulation of cytoplasmic streaming has been publish […] -
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Measuring Forces on the Nucleus Using a Centrifugal Microscope
We have published a study using a centrifugal polarization microscope (CPM) that successfully measured the force required to move the cell nucleus. -
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English Textbook Published
The book Quantitative Biology – A Practical Introduction was published by Springer Nature Singapore. -
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Book Publication: Introduction to Cell Architecture
The book Introduction to Cell Architecture – A New Perspective for Understanding Cells was published on Dec 27th, 2019 by Kohgakusha Publishing.
Publication
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Successful Measurement of Membrane Viscosity
*Yuka Sakuma, Kazunori Yamamoto, Saya Ichihara, Toshihiro Kawakatsu, Kenya Haga, Masayuki Imai, Akatsuki Kimura. Long-range viscosity of the plasma me […] -
3D Simulation of Cytoplasmic Streaming Developed
*Takuji Ishikawa, Takayuki Torisawa, Hirofumi Wada, *Akatsuki Kimura. Swirling Instability mediated by Elastic and Hydrodynamic Couplings in Cytoplasm […] -
Measuring Nuclear Forces with a Centrifugal Microscope
Makoto Goda, Michael Shribak, Zenki Ikeda, Naobumi Okada, Tomomi Tani, Gohta Goshima, Rudolf Oldenbourg, *Akatsuki Kimura. Live-cell imaging under cen […] -
What Determines the Size of the Cell Nucleus?
Rolf Fickentscher, Tomoko Ozawa, Akatsuki Kimura, and *Matthias Weiss. Dynamic allometry of nuclei in early embryos of Caenorhabditis elegans. Phys Re […] -
A Unified Understanding of Nuclear Centration and Spindle Elongation
Shohei Tada, Yoshitaka Yamazaki, Kazunori Yamamoto, Ken Fujii, Takahiro G. Yamada, Noriko F. Hiroi, *Akatsuki Kimura, *Akira Funahashi. Switching from […] -
Analyzing Centrosome Repulsion Using Enucleated Cells
Ken Fujii, Tomo Kondo, *Akatsuki Kimura. Enucleation of the C. elegans embryo revealed dynein-dependent spacing between microtubule asters. Life Scien […]
Event
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Latest events
Oral Presentation at the 48th Annual Meeting of the Molecular Biology Society of…
On Dec 3, 2025, We will organize a workshop at the 48th Annual Meeting of the Molecular Biology Society of Japan (link), to be held at PACIFICO Yokoha […] -
Latest events
NIG Public Lecture
On November 15th (Sat), 2025, the National Institute of Genetics (NIG) Public Lecture will be held online. Akatsuki Kimura will participate in the ses […]
For students
The Cell Architecture Laboratory at the National Institute of Genetics (NIG) welcomes graduate students who wish to join our research. Our lab may be a good fit for you if you:
- Want to explore cells from the perspective of architecture
- Have a background in experimental biology and wish to integrate theoretical or computational approaches
- Have studied physics or mathematics and would like to gain hands-on experience in biological experiments
- Enjoy thinking deeply and pursuing questions with patience and curiosity
If you find our research interesting, please feel free to contact Prof. Akatsuki Kimura by email.